Dataset Information


Gene expression profiling of BHDS-associated renal tumors

ABSTRACT: Renal tumors that arise in individuals with BHD Syndrome represent a molecularly distinct form of renal cancer. In addition, BHD syndrome is due to a mutation the folliculin gene (FLCN). While the folliculin gene is an important tumor suppressor gene, the molecular function of this gene is not well defined. By analyzing tumor samples that contain FLCN mutations, we demonstrate that the FLCN gene is an important regulator of mitochondrial function. Gene expression profiling of BHDS tumors and normal kidney tissues

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeff Klomp  

PROVIDER: E-GEOD-21816 | ArrayExpress | 2010-12-21



altmetric image


Germline mutations in the folliculin (FLCN) gene are associated with the development of Birt-Hogg-Dubé syndrome (BHDS), a disease characterized by papular skin lesions, a high occurrence of spontaneous pneumothorax, and the development of renal neoplasias. The majority of renal tumors that arise in BHDS-affected individuals are histologically similar to sporadic chromophobe renal cell carcinoma (RCC) and sporadic renal oncocytoma. However, most sporadic tumors lack FLCN mutations and the extent  ...[more]

Similar Datasets

| GSE21816 | GEO
2014-07-28 | E-GEOD-49397 | ArrayExpress
2012-06-16 | E-GEOD-38741 | ArrayExpress
2007-06-12 | E-GEOD-7023 | ArrayExpress
2009-02-09 | E-GEOD-14762 | ArrayExpress
2010-05-16 | E-GEOD-17818 | ArrayExpress
2010-01-04 | E-GEOD-17816 | ArrayExpress
| GSE43207 | GEO
2010-05-16 | E-GEOD-17895 | ArrayExpress
2012-12-31 | E-GEOD-43207 | ArrayExpress