Transcriptomics

Dataset Information

2

Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures.


ABSTRACT: Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures. These data support the publication titled "Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures.". Some of the calculations in the publication were derived from an older version of the data available at http://www.iconixpharm.com Copyright (c) 2005 by Iconix Pharmaceuticals, Inc. Guidelines for commercial use: http://www.iconixbiosciences.com/guidelineCommUse.pdf

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Shane Dunlea  Cecelia I Pearson  Barrett P Eynon  Kurt Jarnagin  Georges Natsoulis  Alexander M Tolley  Stuart Tugendreich  Fabrice Leroy  Gert R Lanckriet  Mark Fielden  Laurent El Ghaoui 

PROVIDER: E-GEOD-2187 | ArrayExpress | 2005-05-01

SECONDARY ACCESSION(S): GSE2187PRJNA91243

REPOSITORIES: GEO, ArrayExpress

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Publications

Classification of a large microarray data set: algorithm comparison and analysis of drug signatures.

Natsoulis Georges G   El Ghaoui Laurent L   Lanckriet Gert R G GR   Tolley Alexander M AM   Leroy Fabrice F   Dunlea Shane S   Eynon Barrett P BP   Pearson Cecelia I CI   Tugendreich Stuart S   Jarnagin Kurt K  

Genome research 20050501 5


A large gene expression database has been produced that characterizes the gene expression and physiological effects of hundreds of approved and withdrawn drugs, toxicants, and biochemical standards in various organs of live rats. In order to derive useful biological knowledge from this large database, a variety of supervised classification algorithms were compared using a 597-microarray subset of the data. Our studies show that several types of linear classifiers based on Support Vector Machines  ...[more]

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