Transcriptomics

Dataset Information

3

Salmonella Typhimurium LT2: Control versus naringenin


ABSTRACT: Salmonellosis is one of the leading health problems worldwide. With the rise of drug resistance strains it has become imperative to identify alternative strategies. Naringenin, a flavonone, is present predominantly in grapefruit. Previously we have demonstrated that naringenin is potent inhibitor of cell-cell signaling. In the present study, we provide evidence that naringenin specifically represses 24 genes in the Salmonella pathogenicity island 1, and down-regulates 17 genes involved in flagellar and motility; thereby, attenuating virulence and cell motility, respectively. This is the first molecular evidence to demonstrate effect of naringenin on bacterial virulence and cell motility. One condition experiment, naringenin treated versus DMSO treated. Biological replicates: 3 control, 3 treatment, hybridized in dye-swapped design

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2  

SUBMITTER: G K Jayaprakasha   Bhimanagouda S Patil  Palmy R Jesudhasan  Suresh D Pillai  Amit Vikram  Arul Jayaraman 

PROVIDER: E-GEOD-21873 | ArrayExpress | 2011-05-05

SECONDARY ACCESSION(S): GSE21873PRJNA127063

REPOSITORIES: GEO, ArrayExpress

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Publications

Citrus flavonoid represses Salmonella pathogenicity island 1 and motility in S. Typhimurium LT2.

Vikram Amit A   Jesudhasan Palmy R PR   Jayaprakasha G K GK   Pillai Suresh D SD   Jayaraman Arul A   Patil Bhimanagouda S BS  

International journal of food microbiology 20101124 1


Salmonellosis is one of the leading health problems worldwide. With the rise of drug resistance strains, it has become imperative to identify alternative strategies to counter bacterial infection. Natural products were used historically to identify novel compounds with various bioactivities. Citrus species is a rich source of flavonoids. Naringenin, a flavonone, is present predominantly in grapefruit. Previously we have demonstrated that naringenin is potent inhibitor of cell-cell signaling. The  ...[more]

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