Transcriptomics,Multiomics

Dataset Information

6

Expression data from human skin exposed to solar-simulated radiation with or without sunscreen


ABSTRACT: Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscreen and solar-simulated radiation (ssR). A focal skin area of healthy participants was exposed to ssR at 1 minimal erythema dose (MED), 0.1 MED or 100 J/m2 with or without prior application of sunscreen, or to non-UVB-spectrum of ssR (solar-simulated UVA/visible/infrared radiation: ssA). Skin biopsies were analyzed using expression microarrays. Ninety-eight microarrays from 14 healthy human volunteers were analyzed. Focal skin areas of all 14 volunteers were exposed to 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of solar-simulated radiation (ssR). Eight of the 14 volunteers (Group 1) were also exposed to ssA (ssR minus UVB) that were generated by removing UVB from 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of ssR. Additionally, 6 of the 14 volunteers (Group 2) were treated with sunscreen of sun protection factor (SPF) 15, and exposed to 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of ssR. Biopsy was taken 24 hours after exposure from each focal skin area for RNA extraction.

OTHER RELATED OMICS DATASETS IN: PRJNA128931

SUBMITTER: Lexa R Turner   Atsushi Terunuma  Christine L Tock  Jonathan C Vogel 

PROVIDER: E-GEOD-22083 | ArrayExpress | 2011-10-18

SECONDARY ACCESSION(S): GSE22083PRJNA128931

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-22083.idf.txt Idf
E-GEOD-22083.processed.1.zip Processed
E-GEOD-22083.raw.1.zip Raw
E-GEOD-22083.raw.2.zip Raw
E-GEOD-22083.raw.3.zip Raw
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