Dataset Information


ERalpha ChIP-chip from HeLA-ER cells treated with E2

ABSTRACT: We are studying the mechanisms by which the estrogen receptor, ERalpha, is recruited to and regulates genes with a non-direct DNA binding. We performed ChIP-chip for ERalpha in E2 treated HeLa-ER cells, and looked at 19000 RefSeq genes to determine binding patterns of the receptor at promoters. The experiment was performed in duplicate. ChIP-chip biological replicates for Eralpha in E2 treated HeLa-ER cells are included.

ORGANISM(S): Homo sapiens  

SUBMITTER: Heldring Nina   W. Lee Kraus  Lee Kraus 

PROVIDER: E-GEOD-22099 | ArrayExpress | 2011-02-22



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Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.

Heldring Nina N   Isaacs Gary D GD   Diehl Adam G AG   Sun Miao M   Cheung Edwin E   Ranish Jeffrey A JA   Kraus W Lee WL  

Molecular endocrinology (Baltimore, Md.) 20110217 4

The indirect recruitment (tethering) of estrogen receptors (ERs) to DNA through other DNA-bound transcription factors (e.g. activator protein 1) is an important component of estrogen-signaling pathways, but our understanding of the mechanisms of ligand-dependent activation in this pathway is limited. Using proteomic, genomic, and gene-specific analyses, we demonstrate that a large repertoire of DNA-binding transcription factors contribute to estrogen signaling through the tethering pathway. In a  ...[more]

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