Transcriptomics

Dataset Information

303

Transcription profiling by high throughput sequencing of mouse embryonic and adult brain from F1 hybrids generated from reciprocal crosses of CAST/EiJ and C57BL/6J


ABSTRACT: Genomic imprinting results in the preferential expression of the paternal, or maternal allele of certain genes. We have performed a genome-wide characterization of imprinting in the mouse embryonic and adult brain using F1 hybrid mice generated from reciprocal crosses of CASTEiJ and C57BL/6J mice. We also uncovered genes associated with sex specific parental effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Examination of allele specific expression in the brains of reciprocal crosses of F1 hybrid mice from CASTEiJ and C57BL/6J crosses. Processed data files (GenomicAligned, SNP_calls, TranscriptomeAligned, fRNAdbAligned) and README file linked below as supplementary files.

OTHER RELATED OMICS DATASETS IN: E-GEOD-26284

ORGANISM(S): Mus musculus  

SUBMITTER: Catherine Dulac   Christopher Gregg 

PROVIDER: E-GEOD-22131 | ArrayExpress | 2010-07-08

SECONDARY ACCESSION(S): SRP002811GSE22131PRJNA127583

REPOSITORIES: GEO, ArrayExpress, ENA

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Many animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well  ...[more]

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