Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: André Hanauer Nathalie Rouach Tahir Mehmood Mohamed Ammar Patricia Marques-Pereira Jérémie Sibillec Anne Schneider Solange Pannetier Doulaye Dembele Christelle Thibault-Carpentier
PROVIDER: E-GEOD-22137 | ArrayExpress | 2010-12-22
SECONDARY ACCESSION(S): GSE22137PRJNA127575
REPOSITORIES: GEO, ArrayExpress
Mehmood Tahir T Schneider Anne A Sibille Jérémie J Marques Pereira Patricia P Pannetier Solange S Ammar Mohamed Raafet MR Dembele Doulaye D Thibault-Carpentier Christelle C Rouach Nathalie N Hanauer André A
Human genetics 20101130 3
Coffin-Lowry syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes RSK2, a serine/threonine kinase acting in the MAPK/ERK pathway. The mouse invalidated for the Rps6ka3 (Rsk2-KO) gene displays learning and long-term spatial memory deficits. In the current study, we compared hippocampal gene expression profiles from Rsk2-KO and normal littermate mice to identify changes in molecular pathways. Differential expressi ...[more]