Transcriptomics

Dataset Information

591

MicroRNA signature during the time course of regeneration of the human airway mucociliary epithelium


ABSTRACT: The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). The airway mucociliary epithelium is consituted of three main cell types : ciliated cells, secretory cells and basal cells. We used microRNA microrrays to investigate the signature of microRNA during the four step of regeneration of the airway epithelium. Four time points (ALI-D0, ALI-D7, ALI-D14, ALI-D21) of regeneration of the airway epithelium for 3 donors.

ORGANISM(S): Homo sapiens  

SUBMITTER: K Lebrigand   B Marcet  P Barbry  Kevin Lebrigand 

PROVIDER: E-GEOD-22141 | ArrayExpress | 2011-06-06

SECONDARY ACCESSION(S): GSE22141PRJNA129203

REPOSITORIES: GEO, ArrayExpress

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Publications


Multiciliated cells lining the surface of some vertebrate epithelia are essential for various physiological processes, such as airway cleansing. However, the mechanisms governing motile cilia biosynthesis remain poorly elucidated. We identify miR-449 microRNAs as evolutionarily conserved key regulators of vertebrate multiciliogenesis. In human airway epithelium and Xenopus laevis embryonic epidermis, miR-449 microRNAs strongly accumulated in multiciliated cells. In both models, we show that miR-  ...[more]

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