Genomics,Multiomics

Dataset Information

55

MicroRNA expression profiling of early primary breast cancer to identify prognostic markers and associated pathways


ABSTRACT: Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of age, with lymph node positive tumors, or ER– and/or >3 cm in diameter, received adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for six cycles, in a thrice weekly intravenous regimen. Patients >50 years of age with ER–, lymph node–positive tumors also received CMF. Retrospective clinical study to identify breast cancer prognostic markers and associated pathways. 210 early primary breast cancers were considered who had complete 10-years follow-up, clinical and demographics information. miRNA profiling data.

OTHER RELATED OMICS DATASETS IN: PRJNA128775PRJNA129183PRJNA129185

ORGANISM(S): Homo sapiens  

SUBMITTER: Francesca M Buffa   Carme Camps  Francesca Buffa 

PROVIDER: E-GEOD-22216 | ArrayExpress | 2011-07-08

SECONDARY ACCESSION(S): GSE22216PRJNA129183

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-22216.README.txt Txt
E-GEOD-22216.idf.txt Idf
E-GEOD-22216.processed.1.zip Processed
E-GEOD-22216.sdrf.txt Txt
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Publications

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer.

Buffa Francesca M FM   Camps Carme C   Winchester Laura L   Snell Cameron E CE   Gee Harriet E HE   Sheldon Helen H   Taylor Marian M   Harris Adrian L AL   Ragoussis Jiannis J  

Cancer research 20110707 17


microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated the benefits of a joint microRNA-mRNA analysis in breast cancer. Matched mRNA and microRNA global expression profiling was conducted in a well-annotated cohort of 207 cases with complete 10-year follow-up. Penalized Cox regression including microRNA expression, mRNA expression, and clinical covariates was used to identify microRNAs associate  ...[more]

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