Transcriptomics

Dataset Information

3

Changes in gene expression in implantation and inter-implantation sites by absence of Cbs


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE22187: Changes in gene expression in implantation sites by absence of Cbs GSE22189: Changes in gene expression in inter-implantation sites by absence of Cbs Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Jesus Osada  

PROVIDER: E-GEOD-22310 | ArrayExpress | 2012-05-30

SECONDARY ACCESSION(S): GSE22310PRJNA127373

REPOSITORIES: GEO, ArrayExpress

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Publications

Cystathionine β-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites.

Nuño-Ayala Mario M   Guillén Natalia N   Arnal Carmen C   Lou-Bonafonte José M JM   de Martino Alba A   García-de-Jalón Jose-Antonio JA   Gascón Sonia S   Osaba Lourdes L   Osada Jesús J   Navarro María-Angeles MA  

Physiological genomics 20120522 14


Hyperhomocysteinemia has been reported in human reproduction as a risk factor for early pregnancy loss, preeclampsia, and congenital birth defects like spina bifida. Female infertility was also observed in cystathionine beta synthase-deficient mice (Cbs-KO) as an animal model for severe hyperhomocysteinemia. The aim for the present research was to elucidate the time-point of pregnancy loss and to pinpoint gene and cellular changes involved in the underlying pathological mechanism. By mating 90-d  ...[more]

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