Transcriptomics

Dataset Information

2

Gene expression profile associated with the PDZ ligand-motif of HPV16-E6 oncoprotin in the skin of transgenic mice models


ABSTRACT: The K14E6 transgenic mice developskin hyperplasia,benign tumors and skin cancer. The tumor formation capacity diminishes when E6 lacks its PDZ ligand-motif. This study aims to compare the transciptional profiles of transgenic K14E6 mice with K14E6 Δ146-151 (lacking the PDZ domain) in order to explore the role of PDZ in early skin carcinogenesis. Skin tissue from three different strains of mice were dissected for RNA extraction, processing and hybridization in Affymetrix Mouse Genome 430 2,0 array. We processed three biological replicates per strain. 3 mice were used for each replicate pool for a final RNA concentration of 3 micrograms. The arrays were analyzed using Partek Genomics suite software.

ORGANISM(S): Mus musculus  

SUBMITTER: Claudia Rangel-Escareno   Alfredo Hidalgo-Miranda  Paul F Lambert  Patricio Gariglio  Laura Uribe-Figueroa  Alejandra Roman-Rosales  Enrique Garcia-Villa  José Bonilla-Delgado  Laura I Uribe 

PROVIDER: E-GEOD-22417 | ArrayExpress | 2010-07-27

SECONDARY ACCESSION(S): GSE22417PRJNA128563

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2013-07-01 | E-GEOD-46890 | ArrayExpress
2015-07-13 | E-GEOD-46890 | ExpressionAtlas
| GSE99868 | GEO
2010-07-27 | GSE22417 | GEO
2014-10-30 | PXD001387 | Pride
2013-05-02 | E-GEOD-46558 | ArrayExpress
2011-07-20 | E-GEOD-26809 | ArrayExpress
2013-05-07 | E-GEOD-46660 | ArrayExpress
2014-06-26 | E-GEOD-58811 | ArrayExpress
2015-10-02 | PXD002134 | Pride