Dataset Information


Gene expression data from wild-type and Nlrc5 knockout GM-CSF induced bone marrow dendritic cells infected with Newcastle Disease virus.

ABSTRACT: Nlrc5 is encoding a Nod-like receptor protein NLRC5/NOD27. To check the involvement of Nlrc5 in antiviral response, we examined gene expression profile in wild-type and Nlrc5 knockout GM-CSF bone marrow macrophage with using microarrays. Bone marrow cells were cultured with GM-CSF and harvested on day 6. The induced dendritic cells were then stimulated with NDV at moi 1, collected at 0, 2, and 4 hours after infection. Total RNA was extracted and subjected to microarray experiment according to manufactures' instructions.

ORGANISM(S): Mus musculus  

SUBMITTER: Shizuo Akira   Yutaro Kumagai  Himanshu Kumar  Taro Kawai 

PROVIDER: E-GEOD-22448 | ArrayExpress | 2010-12-22



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NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.

Kumar Himanshu H   Pandey Surya S   Zou Jian J   Kumagai Yutaro Y   Takahashi Ken K   Akira Shizuo S   Kawai Taro T  

Journal of immunology (Baltimore, Md. : 1950) 20101208 2

Nucleotide-binding domain and leucine rich repeat containing gene family receptors (NLRs) are cytosolic proteins that respond to a variety of pathogen and host components to induce inflammatory cytokines. NLRC5 is a recently identified member of the NLR family that has been implicated in positive and negative regulation of antiviral innate immune responses. To clarify whether NLRC5 controls antiviral innate immunity in vivo, we generated NLRC5-deficient mice. Macrophages and dendritic cells deri  ...[more]

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