Transcriptomics

Dataset Information

5

Dnmt3a-dependent non-promoter DNA methylation facilitates transcription of neurogenic genes


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE22473: Murine postnatal subventricular zone (SVZ) neural stem cells (NSCs): Wild-type (WT) vs. Dnmt3a-null (KO) GSE22474: Genome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SVZ) neural stem cells (NSCs) [Agilent] GSE22475: Genome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SVZ) neural stem cells (NSCs) [NimbleGen] Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Yi Eve Sun  

PROVIDER: E-GEOD-22476 | ArrayExpress | 2010-06-24

SECONDARY ACCESSION(S): GSE22476PRJNA128583

REPOSITORIES: GEO, ArrayExpress

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Publications

Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes.

Wu Hao H   Coskun Volkan V   Tao Jifang J   Xie Wei W   Ge Weihong W   Yoshikawa Kazuaki K   Li En E   Zhang Yi Y   Sun Yi Eve YE  

Science (New York, N.Y.) 20100701 5990


DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type-specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such nonproximal promoter DNA methylation are unclear. Here we show that the de novo DNA methyltransferase Dnmt3a is expressed in postnatal neural stem cells (NSCs) and is required for neurogenesis. Genome-wide analysis of postnatal NSCs indicates that Dnmt3a occupies and methylates inter  ...[more]

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