Dataset Information


Gene expression in wild type and mENT1 knock out mice

ABSTRACT: To investigate the functional importance of a nucleoside transporter, the mENT1 (Slc29a1) was knocked out in mice. The gene expression profile was compared between wildtype and mENT1 knock out mice in two tissues. RNA was isolated from heart and kidney from 3 mENT1 knockout and 3 wildtype (FVB/N) mice.Gene expression profiles were compared between the knockout and wild type tissues.

ORGANISM(S): Mus musculus  

SUBMITTER: Carol Cass   Kathryn Graham 

PROVIDER: E-GEOD-22565 | ArrayExpress | 2011-04-27



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Nucleoside transporter gene expression in wild-type and mENT1 knockout mice.

Graham Kathryn K   Yao Sylvia S   Johnson Lorelei L   Mowles Delores D   Ng Amy A   Wilkinson Jodi J   Young James D JD   Cass Carol E CE  

Biochemistry and cell biology = Biochimie et biologie cellulaire 20110401 2

Owing to the overlapping and redundant roles of the seven mammalian nucleoside transporters (NTs), which belong to two protein families (ENTs and CNTs), the physiological importance of individual NTs has been difficult to assess. Mice that have NT genes knocked out can be a valuable tool in gaining an understanding of the NT proteins. We have generated a strain of mice that is homozygous for a disruption mutation between exons 2 and 3 of the mouse equilibrative nucleoside transporter, mENT1. We  ...[more]

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