Transcriptomics

Dataset Information

13

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK) GSE22775: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines) Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Fatima Al-Shahrour  

PROVIDER: E-GEOD-22778 | ArrayExpress | 2010-07-21

SECONDARY ACCESSION(S): GSE22778PRJNA128085

REPOSITORIES: GEO, ArrayExpress

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Publications


RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL  ...[more]

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