Transcriptomics

Dataset Information

356

Comparison of hiPSCs, hESCs and fibroblasts


ABSTRACT: In our study, PRDM14 and NFRkB were found to enhance the reprogramming of human fibroblasts to hiPSCs in the presence of OCT4, SOX2, KLF4, with/without c-MYC (OSK/OSKC). To examnie if the obtained hiPSC share similar expression signature with hESC, we conducted the microarray analysis on the hiPSCs, hESCs and fibroblasts. The result showed that all of the examined hiPSCs resembled hESCs, but differed from fibroblasts MRC5. 4 hiPSC lines, 2 hESC lines and 1 type of fibroblasts were analyzed in total. Each sample is done in duplicates.

ORGANISM(S): Homo sapiens  

SUBMITTER: Na-Yu Chia   Bo Feng  Ng Huck-Hui  NA-YU CHIA 

PROVIDER: E-GEOD-22792 | ArrayExpress | 2010-10-20

SECONDARY ACCESSION(S): GSE22792PRJNA127815

REPOSITORIES: GEO, ArrayExpress

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Publications


The derivation of human ES cells (hESCs) from human blastocysts represents one of the milestones in stem cell biology. The full potential of hESCs in research and clinical applications requires a detailed understanding of the genetic network that governs the unique properties of hESCs. Here, we report a genome-wide RNA interference screen to identify genes which regulate self-renewal and pluripotency properties in hESCs. Interestingly, functionally distinct complexes involved in transcriptional  ...[more]

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