Transcriptomics

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Expression data from G9a overexpression and knockdown lung cancer cell lines


ABSTRACT: G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regionsand is essential for murine embryogenesis . We demonstrate that G9a is endowed with methyltransferase activity to concomitantly repress the downstream effector Ep-CAM, thereby promoting the invasion step of the invasion-metastasis cascade. We used microarrays to detail the G9a regulated gene expression underlying invasion-metastasis cascade and identified distinct classes of up-regulated genes during this process. Lung adenocarcinoma cells with G9a knockdown or overexpression were selected for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Michael Hsiao   Min-Liang Kuo 

PROVIDER: E-GEOD-22810 | ArrayExpress | 2011-12-31

SECONDARY ACCESSION(S): GSE22810PRJNA127899

REPOSITORIES: GEO, ArrayExpress

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