Transcriptomics

Dataset Information

37

Gene expression breast cancer


ABSTRACT: Gene expression profiles were generated from 176 primary breast cancer patients and 12 normal breast samples. This data is used to investigate the clinical relevance of genes of interest from in vitro studies, including FABP5 and DDX1. This Series represents RNA isolated from 176 primary breast cancer patients and 10 normal breast samples. Gene expression is compared between various subgroups depending on their clinical parameters.

ORGANISM(S): Homo sapiens  

SUBMITTER: John Mackey   Kathryn Graham 

PROVIDER: E-GEOD-22820 | ArrayExpress | 2011-04-27

SECONDARY ACCESSION(S): GSE22820PRJNA128101

REPOSITORIES: GEO, ArrayExpress

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Publications

Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy.

Liu Rong-Zong RZ   Graham Kathryn K   Glubrecht Darryl D DD   Germain Devon R DR   Mackey John R JR   Godbout Roseline R  

The American journal of pathology 20110301 3


Recent studies using animal models suggest that expression of FABP5 drives the stimulation of cell growth observed in estrogen receptor (ER)-negative breast cancer cells on exposure to retinoic acid (RA). The purpose of this study was to investigate the clinicopathological significance of FABP5 in breast cancer and to evaluate FABP5 as a prognostic marker and a possible novel therapeutic target in breast cancer. Gene expression microarray analysis revealed a significant correlation between eleva  ...[more]

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