Transcriptomics

Dataset Information

67

Gastrointestinal stromal tumor GIST: gene expresssion and ChIP analyses


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE19396: ETV1 knockdown in GIST cell lines GSE22433: Imatinib Treatment of GIST882 GSE22441: Mapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST). Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Yu Chen  

PROVIDER: E-GEOD-22852 | ArrayExpress | 2010-10-14

SECONDARY ACCESSION(S): GSE22852PRJNA128059

REPOSITORIES: GEO, ArrayExpress

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Publications


Gastrointestinal stromal tumour (GIST) is the most common human sarcoma and is primarily defined by activating mutations in the KIT or PDGFRA receptor tyrosine kinases. KIT is highly expressed in interstitial cells of Cajal (ICCs)-the presumed cell of origin for GIST-as well as in haematopoietic stem cells, melanocytes, mast cells and germ cells. Yet, families harbouring germline activating KIT mutations and mice with knock-in Kit mutations almost exclusively develop ICC hyperplasia and GIST, su  ...[more]

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