Transcriptomics

Dataset Information

77

Expression profiles from a variety of resting and activated human immune cells


ABSTRACT: Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood and bone marrow, treated them to induce activation and/or differentiation, and profiled their gene expression before and after treatment. The twelve cell types are: B cells, CD14+ cells, CD4+ CD45RO+ CD45RA- T cells, CD4+ T cells, CD8+ T cells, IgG/IgA memory B cells, IgM memory B cells, Monocytes, NK cells, Neutrophils, Plasma cells from bone marrow, and Plasma cells from PBMC.

ORGANISM(S): Homo sapiens  

SUBMITTER: Sherman Fong   Flavius Martin  Austin Gurney  Yan Ma  Hilary F Clark  Andrew C Chan  P M Williams  Alex Abbas  Paul Godowski  Menno van Lookeren Campagne  Wenjun Ouyang  Alexander R Abbas  Daryl Baldwin 

PROVIDER: E-GEOD-22886 | ArrayExpress | 2010-07-13

SECONDARY ACCESSION(S): GSE22886PRJNA128145

REPOSITORIES: GEO, ArrayExpress

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Publications

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.

Abbas AR   Baldwin D   Ma Y   Ouyang W   Gurney A   Martin F   Fong S   van Lookeren Campagne M   Godowski P   Williams PM   Chan AC   Clark HF  

Genes and immunity 20050601 4


Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. We have compiled a compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states. Immune Response In Silico (IRIS) is a collection of genes that have been selected for specific expression in immune cells. The expression pattern of IRIS genes recapitulates the phylogeny of immune cells in terms of the lin  ...[more]

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