Transcriptomics

Dataset Information

1

Expression data from MMP-8 wild type and KO mice with or without arthritis


ABSTRACT: Rheumatoid arthritis is an autoimmune disease in which joint inflammation lead to progressive cartilage and bone destruction. Matrix metalloproteinases (MMP) implicated in homeostasis of extracellular matrix (ECM) play a central role in cartilage degradation. The aim of this study was to investigate the role of MMP-8 (collagenase-2) suppression in the K/BxN serum-transfer arthritis model. Three male mice of each following groups: MMP-8 wild type and arthritic mice, MMP-8 wild type without arthritis (wild type control), MMP-8 KO and arthritic mice and MMP-8 KO without arthritis (KO control) were selected for RNA extraction, from ankle joints, and hybridation on Affymetrix microarrays. Male mice were used because they showed a trend to higher arthritis severity compared to female mice. In arthritic mice, ankle joints were taken 7 days after arthritis induction.

ORGANISM(S): Mus musculus  

SUBMITTER: Carlos López-Otin   Samuel García  Carmen Conde  Jerónimo Forteza  Juan J Gómez-Reino  Antonio González 

PROVIDER: E-GEOD-22971 | ArrayExpress | 2010-07-17

SECONDARY ACCESSION(S): GSE22971PRJNA127747

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-22971.README.txt Txt
E-GEOD-22971.idf.txt Idf
E-GEOD-22971.processed.1.zip Processed
E-GEOD-22971.raw.1.zip Raw
E-GEOD-22971.sdrf.txt Txt
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