Transcriptomics,Multiomics

Dataset Information

4

SRF Overexpression Leads to Altered Expression of MicroRNAs and Contributes to Cardiac Hypertrophy


ABSTRACT: The role of SRF in the regulation of microRNA expression and microRNA biogenesis in cardiac hypertrophy has not been well established. In this report, we employed a distinct transgenic mouse model to study the impact of SRF on cardiac microRNA expression and microRNA biogenesis. Cardiac-specific overexpression of SRF (SRF-Tg) led to altered expression of a number of microRNAs. To study the effect of SRF level on cardiac gene expression and function in the mouse heart, we employed the cardiac-specific transgenic approach to increase the SRF protein level in one mouse model. The ventricular tissue samples used for the microRNA array analysis were obtained from 6-month-old wild-type mice and age-matched SRF-Tg mice. The RNA sample isolation and microRNA array were performed in triplets for both wild-type and transgenic mice.

OTHER RELATED OMICS DATASETS IN: PRJNA131163

ORGANISM(S): Mus Musculus

SUBMITTER: Gohar Azhar   Jeanne Y Wei  Scott A Helms  Xiaomin Zhang  Scott Allen Helms 

PROVIDER: E-GEOD-23044 | ArrayExpress | 2011-02-16

SECONDARY ACCESSION(S): GSE23044PRJNA131163

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-23044.idf.txt Idf
E-GEOD-23044.processed.1.zip Processed
E-GEOD-23044.raw.1.zip Raw
E-GEOD-23044.sdrf.txt Txt
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Publications

Regulation of cardiac microRNAs by serum response factor.

Zhang Xiaomin X   Azhar Gohar G   Helms Scott A SA   Wei Jeanne Y JY  

Journal of biomedical science 20110208


Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in cardiac hypertrophy has not been well established. In this report, we employed two distinct transgenic mouse models to study the impact of SRF on cardiac microRNA expression and microRNA biogenesis. Cardiac-specific overexpression of SRF (SRF-Tg) led to altered expression of a number of mi  ...[more]

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