Transcriptomics

Dataset Information

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MicroRNA expression from ARPE-19 cells: control and PDTC treated.


ABSTRACT: The cultured cell line ARPE-19 is frequently employed in studies of rpe function. Here we have identified the microRNAs expressed in RPE cells in the presence and absence of PDTC (pyrrolidine dithiocarbamate), an antioxidant. Analysis used microrNA extracted from untreated cells as a control for cells treated with PDTC

ORGANISM(S): Homo sapiens  

SUBMITTER: Cynthia Jawoski   R K Kutty  Cynthia J Jaworski 

PROVIDER: E-GEOD-23107 | ArrayExpress | 2010-07-24

SECONDARY ACCESSION(S): GSE23107PRJNA131853

REPOSITORIES: GEO, ArrayExpress

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Publications

MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide.

Kutty R Krishnan RK   Samuel William W   Jaworski Cynthia C   Duncan Todd T   Nagineni Chandrasekharam N CN   Raghavachari Nalini N   Wiggert Barbara B   Redmond T Michael TM  

Molecular vision 20100804


MicroRNAs (miRNAs) are important regulators of many cellular functions due to their ability to target mRNAs for degradation or translational inhibition. Previous studies have reported that the expression of microRNA-9 (miR-9) is regulated by retinoic acid and reactive oxygen species (ROS). We have previously shown that N-(4-hydroxyphenyl)-retinamide (4HPR), a retinoic acid derivative, induces ROS generation and apoptosis in cultured human retinal pigment epithelial (RPE) cells, known as ARPE-19  ...[more]

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