Dataset Information


Expression data from DC-induced Hopx-deficient and sufficient regulatory T cells after immunization

ABSTRACT: We found that Hopx is required for the function of DC-induced regulatory T cells in vivo. We used microarrays to identify relevant Hopx-targets in such cells after antigenic re-challenge in vivo. CD25/Foxp3 double positive DC-induced Hopx-deficient and sufficient regulatory T cells were FACS sorted to high purity

ORGANISM(S): Mus musculus  

SUBMITTER: Richard Flavell   Daniel Hawiger 

PROVIDER: E-GEOD-23167 | ArrayExpress | 2010-08-29



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The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.

Hawiger Daniel D   Wan Yisong Y YY   Eynon Elizabeth E EE   Flavell Richard A RA  

Nature immunology 20100829 10

Induced regulatory T cells (iT(reg) cells) can be generated by peripheral dendritic cells (DCs) that mediate T cell unresponsiveness to rechallenge with antigen. The molecular factors required for the function of such iT(reg) cells remain unknown. We report a critical role for the transcription cofactor homeodomain-only protein (Hop; also known as Hopx) in iT(reg) cells to mediate T cell unresponsiveness in vivo. Hopx-sufficient iT(reg) cells downregulated expression of the transcription factor  ...[more]

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