Dataset Information


CpG islands Methylation Profiling by DMH in Epithelial Ovarian Cancer: Screening Set

ABSTRACT: We have systematically profiled DNA methylation at promoter CpG islands (CGIs) in ovarian cancer. Epithelial ovarian tumours, excluding mucinous and clear cell cancers, prospectively collected through a cohort study, were analyzed by differential methylation hybridization (DMH) (Nouzova M et al, 2004) in duplicates. The loci targeted by the custom-designed microarray are the promoter CpG islands (Gardiner-Garden and Frommer, 1987) of the genes involved in the Wnt, p53, AKT/mTOR, BRCA1/2 and Redox pathways, DNA repair (HR, NHEJ and MMR), FA family and IgLON family. 111 ovarian tumor samples were assayed by DMH in duplicates. McrBC digested (Cy5) and undigested (Cy3) samples were competitively hybridized on the Agilent custom-designed microarrays 8x15k.

ORGANISM(S): Homo sapiens  

SUBMITTER: James Paul   Jens M Teodoridis  Robert Brown  Constanze Zeller  David W Millan  Jenny M Hersey  Euan A Stronach  Wei Dai  Nadeem Siddiqui  James M Flanagan  Janet S Graham 

PROVIDER: E-GEOD-23240 | ArrayExpress | 2011-06-01



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