Transcriptomics

Dataset Information

3

Analysis of the miRNA profile associated with c-Src-mediated transformation


ABSTRACT: To address the molecular mechanisms underlying c-Src-mediated tumor progression, we previously developed a model system using Csk-deficient fibroblasts that can be transformed by wild-type c-Src. In this study, we applied this system for the analysis of the potential contribution of miRNA to c-Src-mediated transformation. Pair-wise significance analysis of the microarray indicated that seven miR genes were significantly upregulated and six miRNA genes were downregulated in c-Src-transformed cells with a P value below 0.01 and with a fold change over 2.0. Csk-/- mouse embryonic fibroblasts (Csk-/- MEFs) were transfected with empty vector, c-Src, Csk/c-Src, or Csk. Each sample was run in duplicate.

ORGANISM(S): Mus musculus  

SUBMITTER: Daisuke Okuzaki   Chitose Oneyama  Masato Okada 

PROVIDER: E-GEOD-23426 | ArrayExpress | 2011-02-17

SECONDARY ACCESSION(S): GSE23426PRJNA131047

REPOSITORIES: GEO, ArrayExpress

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