Genomics,Multiomics

Dataset Information

13

Expression data comparing Huh7 CD133+ and CD133- HCC cells


ABSTRACT: To identify candidate genes involved in enhanced tumorigenicity of CD133+ liver tumor-initiating cells Affymetrix Human Genome U133 Plus GeneChip 2.0 HCC cell line Huh7 was sorted into CD133+ and CD133- populations by flow cytometry

OTHER RELATED OMICS DATASETS IN: PRJNA130991PRJNA130993

ORGANISM(S): Homo sapiens  

SUBMITTER: Stephanie Ma  

PROVIDER: E-GEOD-23450 | ArrayExpress | 2012-04-04

SECONDARY ACCESSION(S): GSE23450PRJNA130991

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-23450.README.txt Txt
E-GEOD-23450.additional.1.zip Other
E-GEOD-23450.eSet.r Other
E-GEOD-23450.idf.txt Idf
E-GEOD-23450.processed.1.zip Processed
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Publications

CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.

Tang Kwan Ho KH   Ma Stephanie S   Lee Terence K TK   Chan Yuen Piu YP   Kwan Pak Shing PS   Tong Carol M CM   Ng Irene O IO   Man Kwan K   To Ka-Fai KF   Lai Paul B PB   Lo Chung-Mau CM   Guan Xin-Yuan XY   Guan Xin-Yuan XY   Chan Kwok Wah KW  

Hepatology (Baltimore, Md.) 20120113 3


<h4>Unlabelled</h4>A novel theory in the field of tumor biology postulates that cancer growth is driven by a population of stem-like cells, called tumor-initiating cells (TICs). We previously identified a TIC population derived from hepatocellular carcinoma (HCC) that is characterized by membrane expression of CD133. Here, we describe a novel mechanism by which these cells mediate tumor growth and angiogenesis by systematic comparison of the gene expression profiles between sorted CD133 liver su  ...[more]

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