Dataset Information


Interferon signaling during early experimental malaria infection

ABSTRACT: Microarray profiling of whole blood of immunodeficient mouse strains at 24h after infection with Plasmodium chabaudi. Multiple independent replicates collected for each knockout. RNA isolated and amplified. Hybridized as two-color experiment against a common pooled reference.

ORGANISM(S): Mus musculus  

SUBMITTER: Charlie Kim   Christopher S Nelson  Baidong Hou  Joseph L DeRisi  Charles C Kim  Tony L DeFranco 

PROVIDER: E-GEOD-23565 | ArrayExpress | 2012-11-19



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Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.

Kim Charles C CC   Nelson Christopher S CS   Wilson Emily B EB   Hou Baidong B   DeFranco Anthony L AL   DeRisi Joseph L JL  

PloS one 20121029 10

Type I interferons (T1IFNs) are among the earliest cytokines produced during infections due to their direct regulation by innate immune signaling pathways. Reports have suggested that T1IFNs are produced during malaria infection, but little is known about the in vivo cellular origins of T1IFNs or their role in protection. We have found that in addition to plasmacytoid dendritic cells, splenic red pulp macrophages (RPMs) can generate significant quantities of T1IFNs in response to P. chabaudi inf  ...[more]

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