Dataset Information


MiR-126 over-expression in highly metastatic LM2 breast cancer cells.

ABSTRACT: miR-126 were over-expressed using the miR-Vec system in highly metastatic LM2 cells. The LM2 cell line are described in detail in Minn et al. Nature 2005 This approach was used to conduct an unbiased search for specific miR-126 target genes in breast cancer cells. 4 Samples

ORGANISM(S): Homo sapiens  

SUBMITTER: Halberg Nils   Png Kim  Nils Halberg  Tavazoie Sohail 

PROVIDER: E-GEOD-23905 | ArrayExpress | 2011-12-16



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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png Kim J KJ   Halberg Nils N   Yoshida Mitsukuni M   Tavazoie Sohail F SF  

Nature 20111214 7380

Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-1  ...[more]

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