Transcriptomics

Dataset Information

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A microRNA regulon that mediates endothelial recruitment by metastatic human breast cancer cells.


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE23904: Gene expression profilling of poorly metastatic MDA cells and highly metastatic LM2 cells. GSE23905: miR-126 over-expression in highly metastatic LM2 breast cancer cells. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Nils Halberg  

PROVIDER: E-GEOD-23921 | ArrayExpress | 2011-12-16

SECONDARY ACCESSION(S): GSE23921PRJNA130525

REPOSITORIES: GEO, ArrayExpress

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Publications

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png Kim J KJ   Halberg Nils N   Yoshida Mitsukuni M   Tavazoie Sohail F SF  

Nature 20111214 7380


Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-1  ...[more]

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