Transcriptomics

Dataset Information

32

Expression data from TGF-beta treated Panc-1 pancreatic adenocarcinoma cell line


ABSTRACT: TGF-beta treatment of Panc-1 pancreatic adenocarcinoma cell line on Affymetrix HG_U133_plus_2 arrays; triplicate experiments. The goal of the experiment is to profile temporal gene expression changes during TGF-beta-induced epithelial-mesenchymal transition (EMT). During EMT cancer cells lose their epithelial specifc proteins and gain mesenchymal proteins to acquire migratory and invasive phenotype essential for metastasis. Human Panc-1 pancreatic adenocarcinoma cell line was treated with 5 ng/mL TGF-beta for 48 h to induce EMT. The experiment was repeated 3 times. Samples were assayed using Affymetrix HG_U133_plus_2 arrays with 54675 probe-sets, using standard techniques. Human Panc-1 pancreatic adenocarcinoma cell line was treated with 5 ng/mL TGF-beta for 48 h. The experiment was repeated 3 times. Samples were assayed using Affymetrix HG_U133_plus_2 arrays with 54675 probe-sets, using standard techniques.

REANALYSED by: E-GEOD-23952

ORGANISM(S): Homo sapiens  

SUBMITTER: brian haab   Zachary Wright  Alla Karnovsky  Terry Weymouth  Brian Athey  Venkateshwar G Keshamouni  James Cavalcoli  Vasudeva Mahavisno  Gilbert S Omenn  HV Jagadish  Barbara Mirel  Rork Kuick  Maureen A Sartor 

PROVIDER: E-GEOD-23952 | ArrayExpress | 2010-09-03

SECONDARY ACCESSION(S): GSE23952PRJNA130493

REPOSITORIES: GEO, ArrayExpress

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Publications

Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems.

Maupin Kevin A KA   Sinha Arkadeep A   Eugster Emily E   Miller Jeremy J   Ross Julianna J   Paulino Vincent V   Keshamouni Venkateshwar G VG   Tran Nhan N   Berens Michael M   Webb Craig C   Haab Brian B BB  

PloS one 20100927 9


The ability to selectively detect and target cancer cells that have undergone an epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers such as pancreatic cancer. The remodeling of cellular glycosylation previously has been associated with cell differentiation and may represent a valuable class of molecular targets for EMT.As a first step toward investigating the nature of glycosylation alterations in EMT, we characterized the expression of glycan-related genes in  ...[more]

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