Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques

ABSTRACT: The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. Here we show that both human and zoonotic SARS-CoV strains can infect cynomolgus macaques and resulted in radiological as well as histopathological changes similar to those seen in mild human cases. Viral replication was higher in animals infected with a late human phase isolate compared to a zoonotic isolate. Host responses to the three SARS-CoV strains were similar and only apparent early during infection with the majority of genes associated with interferon signalling pathways.This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use 4 strains, time course, lungs

OTHER RELATED OMICS DATASETS IN: PRJNA130379

ORGANISM(S): Macaca Mulatta

SUBMITTER: Barry Rockx   John Mattoon  Dan Long  Friederike Feldmann  Stephen F Porcella  Lisa Kercher  Don Gardner  Rachel LaCasse  Daniel E Sturdevant  Douglas Brining  Ralph S Baric  Dan Sturdevant  Michael Parnell  Heinz Feldmann  Rebecca Rosenke  Kimmo Virtaneva 

PROVIDER: E-GEOD-23955 | ArrayExpress | 2011-08-31

SECONDARY ACCESSION(S): GSE23955PRJNA130379

REPOSITORIES: GEO, ArrayExpress