Dataset Information


Large intergenic non-coding RNAs as novel modulators of reprogramming: ESCs, fibroblast, and fibroblast-derived iPSC (gene expression)

ABSTRACT: Gene expression profiles of human embryonic stem cells, fibroblasts, and fibroblast-derived induced pluripotent stem cells Total RNA was extracted from human ESCs, fibroblast, and fibroblast-derived iPSC lines, then hybridized to Affymetrix arrays Affymetrix Human Genome U133 Plus 2.0 Array [Affy_HG-U133_Plus_2]

ORGANISM(S): Homo sapiens  

SUBMITTER: John L Rinn   George Q Daley  Nataly Moran Cabili  Sabine Loewer 

PROVIDER: E-GEOD-23968 | ArrayExpress | 2010-11-10



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The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by reprogramming is accompanied by a global remodeling of the epigenome, resulting in altered patterns of gene expression. Here we characterize the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identify numerous lincRNAs whose expression is linked to pluripotency. Among these, we defined ten lincRNAs whose expression was elevated in iP  ...[more]

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