Dataset Information


Large intergenic non-coding RNAs as novel modulators of reprogramming: siRNA (gene expression)

ABSTRACT: lincRNA-ST8SIA3 was depleted using siRNAs and associated gene expression changes were profiled on Affymentrix arrays siRNAs targeting lincRNA-ST8SIA3 were transfected into human induced pluripotent stem cells; non-targeting siRNAs were used as controls GPL570 ;Affymetrix Human Genome U133 Plus 2.0 Array [Affy_HG-U133_Plus_2]

ORGANISM(S): Homo sapiens  

SUBMITTER: John L Rinn   George Q Daley  Nataly Moran Cabili  Sabine Loewer 

PROVIDER: E-GEOD-23973 | ArrayExpress | 2010-11-10



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The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by reprogramming is accompanied by a global remodeling of the epigenome, resulting in altered patterns of gene expression. Here we characterize the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identify numerous lincRNAs whose expression is linked to pluripotency. Among these, we defined ten lincRNAs whose expression was elevated in iP  ...[more]

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