Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Jessica E Treisman Stuart Brown Zuojian Tang Jean-Yves Roignant
PROVIDER: E-GEOD-23997 | ArrayExpress | 2010-10-20
SECONDARY ACCESSION(S): GSE23997SRP003001PRJNA130291
REPOSITORIES: GEO, ArrayExpress, ENA
Roignant Jean-Yves JY Treisman Jessica E JE
Cell 20101001 2
The exon junction complex (EJC) is assembled on spliced mRNAs upstream of exon-exon junctions and can regulate their subsequent translation, localization, or degradation. We isolated mutations in Drosophila mago nashi (mago), which encodes a core EJC subunit, based on their unexpectedly specific effects on photoreceptor differentiation. Loss of Mago prevents epidermal growth factor receptor signaling, due to a large reduction in MAPK mRNA levels. MAPK expression also requires the EJC subunits Y1 ...[more]