Transcriptomics

Dataset Information

2

Transcription profiling by array of human bone engrafted with myeloma cell line Hg, in SCID mice treated with parathyroid hormone or saline


ABSTRACT: The data present global gene expression profile of whole human bones, implanted in SCID mice (SCID-hu model), then engrafted with the myeloma cell line, Hg, and treated with saline or PTH for 4 weeks. SCID-hu mice were prepared by subcutaneous implantation of human bone in SCID mice. The human myeloma cell line, Hg was injected directly into the implanted bone in SCID-hum mice. Upon establishment of myeloma growth as determined by measurement of circulating human immunoglobulins in SCID-hu mice sera, the mice were treated with saline or intermittent PTH (parathyroid hormone, 80 ug/kg/day) for 4 weeks. At the end of the experiment, the human bones from SCID-hu mice were snap frozen in liquid nitrogen. RNA extracted from these bones was subjected to global gene expression profile using Affymetrix U133-Plus microarray.

REANALYSED by: E-GEOD-24068

ORGANISM(S): Homo sapiens  

SUBMITTER: John Shaughnessy   Shmuel Yaccoby 

PROVIDER: E-GEOD-24068 | ArrayExpress | 2013-09-10

SECONDARY ACCESSION(S): GSE24068PRJNA130233

REPOSITORIES: GEO, ArrayExpress

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