Dataset Information


MiR-K10a expression and inhibition

ABSTRACT: Transcriptional profiling of BJAB cells expressing miR-K10a and BCBL cells treated with miR-K10a inhibitor. To identify host RNA targets of KSHV miRNAs, we took advantage of the observation that RNAs targeted by miRNAs often display small reductions in their steady-state levels, perhaps as a result of their impaired translation. Accordingly, we examined cellular transcript accumulation by array-based expression profiling under three sets of conditions in which KSHV miRNAs were expressed or inhibited. Cells transfected with negative control miRNA compared to miR-K10a or negative miRNA inhibitor compared to miR-K10a inhibitor. The publication associated with this data set is about human TNFRSF12A/TWEAKR being targeted by KSHV miR-K10a.

ORGANISM(S): Homo sapiens  

SUBMITTER: Don Ganem   Joseph M Ziegelbauer 

PROVIDER: E-GEOD-24069 | ArrayExpress | 2010-11-10



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Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microRNA prevents TWEAK-induced apoptosis and inflammatory cytokine expression.

Abend Johanna R JR   Uldrick Thomas T   Ziegelbauer Joseph M JM  

Journal of virology 20100915 23

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is the causative agent of KS, the second most common AIDS-associated malignancy. KSHV expresses at least 18 different mature microRNAs (miRNAs) during latency. To identify cellular targets of KSHV miRNAs, we have analyzed a previously reported series of microarrays examining changes in cellular gene expression in the presence of KSHV miRNAs. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) receptor (TWEAKR) was among the most  ...[more]

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