Transcriptomics,Multiomics

Dataset Information

7

Transcription profiling of S. cerevisiae spt10 null mutant and wild type cultures


ABSTRACT: Comparison of gene expression patterns for wild type yeast (BJ5459) and spt10-null::URA3 cells. Triplicate samples. Experiment Overall Design: Three RNA samples from wild type, spt10-null and spt10-C388S cells were prepared independently on three occasions. These nine RNA samples were used to make cRNA and hybridised separately to Affymetrix S98 arrays at the same time.

OTHER RELATED OMICS DATASETS IN: PRJNA93275PRJNA91617

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: David Johannes Clark  

PROVIDER: E-GEOD-2407 | ArrayExpress | 2007-07-07

SECONDARY ACCESSION(S): GSE2407GDS1270PRJNA91617

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-2407.README.txt Txt
E-GEOD-2407.idf.txt Idf
E-GEOD-2407.processed.1.zip Processed
E-GEOD-2407.sdrf.txt Txt
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Publications

The DNA-binding domain of the yeast Spt10p activator includes a zinc finger that is homologous to foamy virus integrase.

Mendiratta Geetu G   Eriksson Peter R PR   Shen Chang-Hui CH   Clark David J DJ  

The Journal of biological chemistry 20060116 11


The yeast SPT10 gene encodes a putative histone acetyltransferase that binds specifically to pairs of upstream activating sequence (UAS) elements found only in the histone gene promoters. Here, we demonstrate that the DNA-binding domain of Spt10p is located between residues 283 and 396 and includes a His(2)-Cys(2) zinc finger. The binding of Spt10p to the histone UAS is zinc-dependent and is disabled by a zinc finger mutation (C388S). The isolated DNA-binding domain binds to single histone UAS e  ...[more]

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