Transcriptomics

Dataset Information

124

Hypoxia, ketoconazole, and the UPC2 gene in Candida albicans


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE24073: Transcriptional profile of Candida albicans during Hypoxic conditions. GSE24074: Transcriptional profile of Candida albicans DAY286 culture without ketoconazole versus DAY286 culture with 0.04 μg/ml ketoconazole, both at 20% oxygen (normoxia). GSE24075: Transcriptional profile of Candida albicans DAY286 versus UPC2 delete, both at 1% oxygen (hypoxia). Refer to individual Series

ORGANISM(S): Candida albicans  

SUBMITTER: Alessandro Guida  

PROVIDER: E-GEOD-24076 | ArrayExpress | 2010-11-15

SECONDARY ACCESSION(S): GSE24076PRJNA130243

REPOSITORIES: GEO, ArrayExpress

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Publications

Regulation of the hypoxic response in Candida albicans.

Synnott John M JM   Guida Alessandro A   Mulhern-Haughey Siobhan S   Higgins Desmond G DG   Butler Geraldine G  

Eukaryotic cell 20100924 11


The regulation of the response of Candida albicans to hypoxic (low-oxygen) conditions is poorly understood. We used microarray and other transcriptional analyses to investigate the role of the Upc2 and Bcr1 transcription factors in controlling expression of genes involved in cell wall metabolism, ergosterol synthesis, and glycolysis during adaptation to hypoxia. Hypoxic induction of the ergosterol pathway is mimicked by treatment with sterol-lowering drugs (ketoconazole) and requires UPC2. Expre  ...[more]

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