Transcriptomics

Dataset Information

6

Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection


ABSTRACT: Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action" Copyright (c) 2005 by Iconix Pharmaceuticals, Inc. Guidelines for commercial use: http://www.iconixbiosciences.com/guidelineCommUse.pdf Keywords: other

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Georges Natsoulis   Naiomi Breckenridge  Joe Ferng  Eser Ayanoglu  Christopher McSorley  Silke Thode  Li Gong  Christopher Hu  Peter Nguyen  Simone M Nicholson  May D Lee  Antoaneta Vladimirova  Keith A Bostian  Cecelia I Pearson  Ramesh V Nair  Barrett P Eynon  Kurt Jarnagin  Alexander M Tolley  Michael S Judo  Mark R Fielden  Alan H Roter  James M Minor  Jian Yang  Siqi Tan  Susan Y Fujimoto  Hang Pham  Radha Idury  Dongxu Sun  John T Calvin  Kyle L Kolaja  Mike L Furness  Zhiming Zhou  Mark Fielden 

PROVIDER: E-GEOD-2409 | ArrayExpress | 2005-05-31

SECONDARY ACCESSION(S): GSE2409PRJNA91621

REPOSITORIES: GEO, ArrayExpress

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Publications

Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.

Ganter Brigitte B   Tugendreich Stuart S   Pearson Cecelia I CI   Ayanoglu Eser E   Baumhueter Susanne S   Bostian Keith A KA   Brady Lindsay L   Browne Leslie J LJ   Calvin John T JT   Day Gwo-Jen GJ   Breckenridge Naiomi N   Dunlea Shane S   Eynon Barrett P BP   Furness L Mike LM   Ferng Joe J   Fielden Mark R MR   Fujimoto Susan Y SY   Gong Li L   Hu Christopher C   Idury Radha R   Judo Michael S B MS   Kolaja Kyle L KL   Lee May D MD   McSorley Christopher C   Minor James M JM   Nair Ramesh V RV   Natsoulis Georges G   Nguyen Peter P   Nicholson Simone M SM   Pham Hang H   Roter Alan H AH   Sun Dongxu D   Tan Siqi S   Thode Silke S   Tolley Alexander M AM   Vladimirova Antoaneta A   Yang Jian J   Zhou Zhiming Z   Jarnagin Kurt K  

Journal of biotechnology 20050901 3


Successful drug discovery requires accurate decision making in order to advance the best candidates from initial lead identification to final approval. Chemogenomics, the use of genomic tools in pharmacology and toxicology, offers a promising enhancement to traditional methods of target identification/validation, lead identification, efficacy evaluation, and toxicity assessment. To realize the value of chemogenomics information, a contextual database is needed to relate the physiological outcome  ...[more]

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