Transcriptomics

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Gene and exon expression change in cardiac hypertrophy with pressure overload


ABSTRACT: Pathological cardiac hypertrophy was induced by pressure overload on the heart. We performed genome-wide exon array experiments with left ventricles of mice with 1 week and 4 week of transverse aortic constriction (TAC). The exon level analysis revealed widespread regulation of alternative splicing and alternative polyadenylation during hypertrophy. Exon and gene expression changes were examined in 1 week and 4 week TAC-operated hearts compared to sham-operated hearts. We used C57/BL6 wildtype mice, and their left ventricles were subject to surgery (each n=2).

ORGANISM(S): Mus musculus  

SUBMITTER: Bin Tian   Takahisa Matsuda  Ji-Yeon Park  Stephen F Vatner  Wencheng Li  Junichi Sadoshima  Dinghai Zheng  Jiyeon Park  Yun Zhao 

PROVIDER: E-GEOD-24242 | ArrayExpress | 2011-05-01

SECONDARY ACCESSION(S): GSE24242PRJNA133015

REPOSITORIES: GEO, ArrayExpress

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