Transcriptomics

Dataset Information

5

Biomarkers for Down Syndrome screening in murine fetal liver and placenta


ABSTRACT: The Ts1Cje mouse strain (Sago, 1998) contains a segmental trisomy of mouse chromosome 16 orthologous to the region of human chromosome 21 commonly associated with Down Syndrome. In this study, fetuses were obtained from wildtype mothers bred with either wildtype or Ts1Cje males. Gene expression profiles in fetal liver and placenta of wildtype and Ts1Cje fetuses were compared, to identify potential markers for application in human prenatal DS screening. A 48 array study with 24 arrays for placenta and 24 for fetal liver. For each tissue we used RNA from 24 individual embryos, i.e. six male and six female embryos from both genotypes.

ORGANISM(S): Mus musculus  

SUBMITTER: Jeroen Pennings  

PROVIDER: E-GEOD-24272 | ArrayExpress | 2011-05-11

SECONDARY ACCESSION(S): GSE24272PRJNA133009

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening.

Pennings Jeroen L A JL   Rodenburg Wendy W   Imholz Sandra S   Koster Maria P H MP   van Oostrom Conny T M CT   Breit Timo M TM   Schielen Peter C J I PC   de Vries Annemieke A  

PloS one 20110414 4


BACKGROUND: As a first step to identify novel potential biomarkers for prenatal Down Syndrome screening, we analyzed gene expression in embryos of wild type mice and the Down Syndrome model Ts1Cje. Since current Down Syndrome screening markers are derived from placenta and fetal liver, these tissues were chosen as target. METHODOLOGY/PRINCIPAL FINDINGS: Placenta and fetal liver at 15.5 days gestation were analyzed by microarray profiling. We confirmed increased expression of genes located at the  ...[more]

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