Transcriptomics

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Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE24285: Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 chromosomal tiling arrays) GSE24286: Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 promoter tiling arrays) GSE24320: Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (high-throughput small RNA sequencing) Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Yi Eve Sun  

PROVIDER: E-GEOD-24329 | ArrayExpress | 2010-09-29

SECONDARY ACCESSION(S): GSE24329PRJNA132739

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome.

Wu Hao H   Tao Jifang J   Chen Pauline J PJ   Shahab Atif A   Ge Weihong W   Hart Ronald P RP   Ruan Xiaoan X   Ruan Yijun Y   Sun Yi E YE  

Proceedings of the National Academy of Sciences of the United States of America 20101004 42


MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of neural development, including neurogenesis, dendritogenesis, and synapse formation. Rett syndrome (RTT) is a progressive neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Although Mecp2 is known to act as a global transcriptional regula  ...[more]

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