Transcriptomics

Dataset Information

31

Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background


ABSTRACT: Transcriptional profiling of E14.5 XY germ cells (marked with Oct4-EGFP transgene) from two strain backgrounds (C57BL/6J and 129S1/SvImJ) that differ in their susceptibility to testicular teratomas. Two condition experiment. For each sample, Oct4-EGFP+ germ cells from all XY embyos within a litter were pooled. For the C57BL/6J background, n=3 pooled biological replicates were profiled, and n=2 replicates were obtained and profiled for 129S1/SvImJ.

ORGANISM(S): Mus musculus  

SUBMITTER: Steven Munger  Matthew S Cook   Steven C Munger   Blanche Capel    

PROVIDER: E-GEOD-24340 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE24340PRJNA132899

REPOSITORIES: GEO, ArrayExpress

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Publications

Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.

Cook Matthew S MS   Munger Steven C SC   Nadeau Joseph H JH   Capel Blanche B  

Development (Cambridge, England) 20101129 1


Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1(Ter/Ter) mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto mixed background Dnd1(Ter/Ter) mutants, where teratomas do not typically develop, resulted in a high incidence of teratomas. However, when Dnd1(Ter/Ter); Bax(-/-) double mutants were backcrossed to C57BL/6J, no tumors arose. Dnd1(Ter/Ter) germ cells show a strong downregulati  ...[more]

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