Transcriptomics

Dataset Information

3

Identification of Gene Products Involved in the Oxidative Stress Response of Moraxella catarrhalis: Evaluation of OxyR dependent Genes


ABSTRACT: Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E and M. catarrhalis oxyR mutant response to 50 mM hydrogen peroxide. Wild-type cells and oxyR mutant cells were exposed to 50 mM hydrogen peroxide for 15 minutes. RNA was extracted and DNA microarray analysis performed. 4 biologic replicates were studied. One dye swap was included in this series analysis. Control oxyR mutant cells exposed to water

ORGANISM(S): Moraxella catarrhalis  

SUBMITTER: Eric J Hansen   Wei Z Liu  Todd C Hoopman  Todd C. Hoopman 

PROVIDER: E-GEOD-24351 | ArrayExpress | 2010-12-07

SECONDARY ACCESSION(S): GSE24351PRJNA132801

REPOSITORIES: GEO, ArrayExpress

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Publications

Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis.

Hoopman Todd C TC   Liu Wei W   Joslin Stephanie N SN   Pybus Christine C   Brautigam Chad A CA   Hansen Eric J EJ  

Infection and immunity 20101122 2


Moraxella catarrhalis is subjected to oxidative stress from both internal and environmental sources. A previous study (C. D. Pericone, K. Overweg, P. W. Hermans, and J. N. Weiser, Infect. Immun. 68:3990-3997, 2000) indicated that a wild-type strain of M. catarrhalis was very resistant to killing by exogenous hydrogen peroxide (H₂O₂). The gene encoding OxyR, a LysR family transcriptional regulator, was identified and inactivated in M. catarrhalis strain O35E, resulting in an increase in sensitivi  ...[more]

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