Transcriptomics

Dataset Information

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Gene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves


ABSTRACT: To investigate effects of intake of Eucommia ulmoides leaves on hyperlipidemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that Eucommia ulmoides leaves up-regulated the gene expression involved in alpha-, beta-, and omega-oxidation of fatty acids, mainly relating to peroxisome proliferator-activated receptor signaling pathway. Rats were fed a high-fat diet and high-fructose water without/with orally administration of Eucommia ulmoides leaves for 5 weeks. Livers were taken for RNA extraction and hybridization on Agilent microarrays.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Toshiyuki Ohsawa   Yukihiro Kobayashi  Takahiko Hirokawa  Nobuyoshi Aoki  Testuya Hiroi  Mayumi Araki  Takashi Kojima  Maki Miyazawa 

PROVIDER: E-GEOD-24377 | ArrayExpress | 2011-08-21

SECONDARY ACCESSION(S): GSE24377PRJNA132859

REPOSITORIES: GEO, ArrayExpress

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Publications

Facilitative effects of Eucommia ulmoides on fatty acid oxidation in hypertriglyceridaemic rats.

Kobayashi Yukihiro Y   Hiroi Tetsuya T   Araki Mayumi M   Hirokawa Takahiko T   Miyazawa Maki M   Aoki Nobuyoshi N   Kojima Takashi T   Ohsawa Toshiyuki T  

Journal of the science of food and agriculture 20110804 2


BACKGROUND: Tea made from Eucommia ulmoides leaves is widely consumed as a health food, since recent studies have revealed various pharmacological effects of the tea, e.g. a hypotriglyceridaemic effect. This study was conducted to elucidate the mechanisms underlying the plasma triglyceride-lowering effect of E. ulmoides leaves. RESULTS: Rats were divided into four groups: a normal group, a group fed a high-fat/high-fructose diet (untreated group) and two groups fed a high-fat/high-fructose diet  ...[more]

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