Dataset Information


Sprouting transcriptome in cortical neurons

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE24440: Sprouting transcriptome in cortical neurons: young GSE24441: Sprouting transcriptome in cortical neurons: aged Refer to individual Series

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Giovanni Coppola  

PROVIDER: E-GEOD-24442 | ArrayExpress | 2010-11-15



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An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.

Li Songlin S   Overman Justine J JJ   Katsman Diana D   Kozlov Serguei V SV   Donnelly Christopher J CJ   Twiss Jeffery L JL   Giger Roman J RJ   Coppola Giovanni G   Geschwind Daniel H DH   Carmichael S Thomas ST  

Nature neuroscience 20101107 12

Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a new connection after stroke is not known. We selectively isolated neurons that sprout a new connection in cortex after stroke and compared their whole-genome expression profile to that of adjacent, non-sprouting neurons. This 'sprouting transcriptome' identified a neuronal growth program that consist  ...[more]

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