Transcriptomics

Dataset Information

35

Deep sequencing of small RNAs from C. elegans during aging


ABSTRACT: Aging is under genetic control in C. elegans but the mechanisms of lifespan regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism and one miRNA has been previously implicated in lifespan. Here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most up-regulated miRNAs lead to lifespan defects. Some act to promote normal lifespan and stress resistance while others inhibit these phenomena. We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway. Our findings reveal that miRNAs both positively and negatively influence lifespan. Since several miRNAs up-regulated during aging regulate genes in conserved pathways of aging and thereby influence lifespan in C. elegans, we propose that miRNAs may play important roles in stress response and aging of more complex organisms. 4 sample examined: Wild-type (N2) and long-lived daf-2(e1379) animals at days 0 and 10 of adulthood

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Frank Slack  Alexandre de Lencastre   ALEXANDRE DE LENCASTRE    

PROVIDER: E-GEOD-24510 | ArrayExpress| 2014-06-02

SECONDARY ACCESSION(S): GSE24510PRJNA132585

REPOSITORIES: GEO, ArrayExpress

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Publications

MicroRNAs both promote and antagonize longevity in C. elegans.

de Lencastre Alexandre A   Pincus Zachary Z   Zhou Katherine K   Kato Masaomi M   Lee Siu Sylvia SS   Slack Frank J FJ  

Current biology : CB 20101202 24


aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span.here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life span and stress resistance, whereas  ...[more]

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