Transcriptomics

Dataset Information

33

Expression variation in the mouse retina


ABSTRACT: Expression analysis of multiple mouse strains across two developmental timepoints to determine both strain specific and temporal expression of genes in the mouse retina A total of 29 retinas were collected from 15 mice of each strain at similar time points during the day. Equimolar amounts of RNA isolated from ten retinas were pooled into three separate pools from each strain and time point, then hybridized to Affymetrix Mouse 420A 2.0 GeneChip arrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew Sachs  Lakeisha Cox   Alexandra Silveira   Barrett Leehy   Sarah Schenk   Margaret DeAngelis   Arne Nystuen   Neena Haider   Yuan Yang   Austin Jelcick   Margaux Morrison   Fang Qiu    

PROVIDER: E-GEOD-24512 | ArrayExpress| 2012-06-26

SECONDARY ACCESSION(S): GSE24512PRJNA132589

REPOSITORIES: GEO, ArrayExpress

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Publications


Variation in genetic background can significantly influence the phenotypic outcome of both disease and non-disease associated traits. Additionally, differences in temporal and strain specific gene expression can also contribute to phenotypes in the mammalian retina. This is the first report of microarray based cross-strain analysis of gene expression in the retina investigating genetic background effects. Microarray analyses were performed on retinas from the following mouse strains: C57BL6/J, A  ...[more]

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