Transcriptomics

Dataset Information

5

Expression variation in the mouse retina


ABSTRACT: Expression analysis of multiple mouse strains across two developmental timepoints to determine both strain specific and temporal expression of genes in the mouse retina A total of 29 retinas were collected from 15 mice of each strain at similar time points during the day. Equimolar amounts of RNA isolated from ten retinas were pooled into three separate pools from each strain and time point, then hybridized to Affymetrix Mouse 420A 2.0 GeneChip arrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Andrew Sachs   Lakeisha Cox  Alexandra Silveira  Barrett Leehy  Sarah Schenk  Margaret DeAngelis  Arne Nystuen  Neena Haider  Yuan Yang  Austin Jelcick  Margaux Morrison  Fang Qiu 

PROVIDER: E-GEOD-24512 | ArrayExpress | 2012-03-15

SECONDARY ACCESSION(S): GSE24512PRJNA132589

REPOSITORIES: GEO, ArrayExpress

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Publications


Variation in genetic background can significantly influence the phenotypic outcome of both disease and non-disease associated traits. Additionally, differences in temporal and strain specific gene expression can also contribute to phenotypes in the mammalian retina. This is the first report of microarray based cross-strain analysis of gene expression in the retina investigating genetic background effects. Microarray analyses were performed on retinas from the following mouse strains: C57BL6/J, A  ...[more]

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