Genomics

Dataset Information

299

Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners


ABSTRACT: Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners Examination of RUNX1 binding in K562 cells, before and following TPA induction and CMK cells. Examination of GATA1 and FOS binding and H3K4me1 and H3K27me3 modification levels following TPA induction in K562 cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ram Jaschek   Niv Pencovich 

PROVIDER: E-GEOD-24777 | ArrayExpress | 2011-01-10

SECONDARY ACCESSION(S): SRP003882GSE24777PRJNA133387

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models.

Pencovich Niv N   Jaschek Ram R   Tanay Amos A   Groner Yoram Y  

Blood 20101019 1


Specific interactions of transcription factors (TFs) with their targets are crucial for specifying gene expression programs during cell differentiation. How specificity is maintained despite limited selectivity of individual TF-DNA interactions is not fully understood. RUNX1 TF is among the most frequently mutated genes in human leukemia and an important regulator of megakaryopoiesis. We used megakaryocytic cell lines to characterize the network of RUNX1 targets and cooperating TFs in differenti  ...[more]

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